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Reach your goals with our best pre-workout
Backed by 56 scientific studies, REAL FUEL is the best pre-workout supplement formulated by Gensan that stimulates concentration and boosts your performance. Contains creatine, citrulline, BCAAs, caffeine. Flavor: ACE.
expiry 03/31/2028

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INFORMAZIONI NUTRIZIONALI E INGREDIENTI
Ingredienti:
Creatina monoidrato, L-citrullina DL-malato, beta alanina, L-leucina, taurina, L-arginina alfa-chetoglutarato (AAKG), acidificante: acido citrico; destrine resistenti, addensante: isomalto; L-isoleucina, L-valina, aromi, succo concentrato disidratato di arancia, carota e limone, rodiola (Rhodiola rosea L.) radice e.s. tit. 3% rosavine totali, agente antiagglomerante: biossido di silicio; CAVACURMIN® [curcuma (Curcuma longa L.), gamma-ciclodestrina] rizoma e.s. tit. 15% curcuminoidi, L-teanina, caffeina anidra, edulcorante: sucralosio; stabilizzanti: esteri di saccarosio degli acidi grassi, idrossi-propil-metilcellulosa; piridossina cloridrato (vitamina B6), pepe nero (Piper nigrum L.) frutto e.s. tit. 95% piperina, acido pteroil-monoglutammico (acido folico), cianocobalamina (vitamina B12).
MODALITÀ D'USO
- The recommended daily intake is 15 g (equal to 1 level scoop) dissolved in 300 ml of water.
A 15 g dose consists of:
- 3 g of Creatine for an instant increase in phosphocreatine (CP) stores [1], which is of fundamental importance for ATP synthesis in short and medium-duration high-intensity efforts; to ensure adequate cell hydration and hypertonicity [2], given the fluid loss due to physical activity; for a reduction in fatigue [3] in chronic states and sleep deprivation [4]; for better glucose uptake within the cell [5] and therefore its adequate use for energy purposes; for increasing lean mass and the diameter of type I, IIa, and IIx muscle fibers [6].
- L-Citrulline is an amino acid that promotes nitric oxide synthesis (NOS) [16,17], which doubles the levels of L-Arginine and L-Ornithine already present in the body [15], thereby increasing the vasodilatory effect and thus a greater influx of nutrients. Citrulline promotes glycogenolysis and glycolysis, thereby increasing ATP production [18], which is essential for continuous muscle contraction. Furthermore, it mitigates the depletion of phosphocreatine stores (the active form of creatine) and promotes their restoration [19], thus reducing the waiting time to repeat an explosive movement.
- L-Arginine alpha-ketoglutarate is an amino acid that directly induces nitric oxide synthesis [20], thereby increasing blood flow also thanks to the coadjuvant action of Citrulline [21]. L-Arginine administration has been shown to increase anaerobic performance in sprints and delay the onset of fatigue symptoms [23]. L-Arginine also has a protective function for pancreatic β cells and improves insulin secretion [22]. The combination of L-Arginine and Creatine increases anaerobic performance and muscle mass, in addition to improving the rate of ATP resynthesis during muscle effort [24].
- Taurine is another essential amino acid for muscle function in both the musculoskeletal system and the heart, as well as the eyes. In sports, it is very useful in performance by improving aerobic capacity [26,27].
- β-Alanine is a modified version of the amino acid ⍺-alanine, and is the most important extracellular substrate for increasing carnosine concentrations within the cell [28], responsible for the buffering effect on intramuscular pH, as well as being a powerful anti-aging [29] and antioxidant molecule [30], reducing protein alteration from reactive oxygen species (ROS) [31], reactive nitrogen species (RNS) [32], and advanced glycation end products (AGEs) [33]. β-alanine has been shown to increase power expression in strength endurance [34,35] and in the endurance of sprinters in repeated maximal efforts [36]. β-alanine is particularly effective in all sports where performance ranges from 60 to 240 seconds [37], as well as in all sports with intermittent efforts.
- Caffeine is a natural alkaloid classified as a nootropic, meaning a stimulant that acts at the brain level giving greater focus, reactivity, and cognition, but it is also a mild anti-inflammatory, antioxidant, associated with the prevention of gastrointestinal neoplasms [38,39]. L-Theanine is an amino acid found in tea that, together with Caffeine, works synergistically to increase concentration, mitigating the undesirable effects of the latter if in excess [40].
- A pool of branched-chain amino acids, BCAAs in a 2:1:1 ratio (L-Leucine 1.0 g; L-Isoleucine 0.5 g; L-Valine 0.5 g), primarily promotes glucose uptake via the PI3K/aPKC pathway, independent of the mTOR pathway, and its utilization in the cell [7][8][9]. Furthermore, they perform a particular neuronal activation function [10], as they would compete with the same tryptophan uptake pathway [11], responsible for increased fatigue during training, so their integration before and during training would increase neuronal excitation via mTOR [12], thus allowing greater focus and a delay in the onset of fatigue [13][14].
- Rhodiola Rosea is an adaptogen associated with a reduction in physical and mental fatigue [41], an increase in cognitive function [42,43,44,45] and neuro-motor function [43], a reduction in the margin of error [43], an increase in the attention threshold [46] and reaction time to stimuli [46], and more generally an improvement in the sense of well-being [43,44].
- CAVACURMIN® is a registered trademark dry extract of curcumin. Curcumin has been shown to prevent and block the degeneration of cognitive function in states of chronic stress [47,48]; furthermore, curcuminoids reduce depressive symptoms by increasing well-being [49,50,51,52]. Curcumin has a protective function at the endothelial level and increases nitric oxide production [53,54], and finally, it has been shown to be a molecule with antioxidant and anti-inflammatory properties [55]. Piper nigrum l. increases the absorption of curcuminoids by twentyfold [56].
BIBLIOGRAFIA
- Brault JJ, Towse TF, Slade JM, Meyer RA. Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation. Int J Sport Nutr Exerc Metab. 2007 Dec;17(6):624-34. PubMed PMID: 18156666.
- Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):70-91. PubMed PMID: 17460334.
- Watanabe A, Kato N, Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res. 2002 Apr;42(4):279-85. PubMed PMID:11985880.
- McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, Dye L, Hodgson C, Draper N. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006 Mar;185(1):93-103. Epub 2006 Jan 17. PubMed PMID: 16416332.
- Op 't Eijnde B, Ursø B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes. 2001 Jan;50(1):18-23. PubMed PMID: 11147785.
- Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003 Jun;13(2):198-226. PubMed PMID: 12945830.
- Nishitani S, Matsumura T, Fujitani S, Sonaka I, Miura Y, Yagasaki K. Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun. 2002 Dec 20;299(5):693-6. PubMed PMID: 12470633.
- Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E. Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J. 2004 Dec;18(15):1894-6. Epub 2004 Oct 12. PubMed PMID: 15479767.
- Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucoseoxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1683-93. Epub 2007 Feb 13. PubMed PMID: 17299083.
- Blomstrand E. A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006 Feb;136(2):544S-547S. PubMed PMID: 16424144.
- Blomstrand E, Møller K, Secher NH, Nybo L. Effect of carbohydrate ingestion on brain exchange of amino acids during sustained exercise in human subjects. Acta Physiol Scand. 2005 Nov;185(3):203-9. PubMed PMID: 16218925.
- Ament W, Verkerke GJ. Exercise and fatigue. Sports Med. 2009;39(5):389-422. doi: 10.2165/00007256-200939050-00005. Review. PubMed PMID: 19402743.
- Jin G, Kataoka Y, Tanaka M, Mizuma H, Nozaki S, Tahara T, Mizuno K, Yamato M, Watanabe Y. Changes in plasma and tissue amino acid levels in an animal model of complex fatigue. Nutrition. 2009 May;25(5):597-607. doi:10.1016/j.nut.2008.11.021. Epub 2009 Feb 11. PubMed PMID: 19216057.
- BLOMSTRAND, E. , HASSMÉN, P. and NEWSHOLME, E. A. (1991), Effect of branched‐chain amino acid supplementation on mental performance. Acta Physiologica Scandinavica, 143: 225-226. doi:1111/j.1748-1716.1991.tb09225.x
- Thibault R, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, Darmaun D. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. 2011 Dec;30(6):807-11. doi: 10.1016/j.clnu.2011.06.005. Epub 2011 Jul 5. PubMed PMID: 21733603.
- Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling; L Castillo, L Beaumier, A M Ajami, V R Young; Proceedings of the National Academy of Sciences Oct 1996, 93 (21) 11460-11465; DOI: 10.1073/pnas.93.21.11460
- Rougé C, Des Robert C, Robins A, Le Bacquer O, Volteau C, De La Cochetière MF, Darmaun D. Manipulation of citrulline availability in humans. Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1061-7. Epub 2007 Sep 27. PubMed PMID: 17901164.
- Faure C, Morio B, Chafey P, Le Plénier S, Noirez P, Randrianarison-Huetz V, Cynober L, Aussel C, Moinard C. Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats. Proteomics. 2013 Jul;13(14):2191-201. doi: 10.1002/pmic.201200262. Epub 2013 Jun 10. PubMed PMID: 23592530.
- Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002 Aug;36(4):282-9. PubMed PMID: 12145119; PubMed Central PMCID: PMC1724533.
- Bailey SJ, Winyard PG, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, Jones AM. Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance. J Appl Physiol (1985). 2010 Nov;109(5):1394-403. doi: 10.1152/japplphysiol.00503.2010. Epub 2010 Aug 19. PubMed PMID: 20724562.
- Figueroa A, Sanchez-Gonzalez MA, Wong A, Arjmandi BH. Watermelon extract supplementation reduces ankle blood pressure and carotid augmentation index in obese adults with prehypertension or hypertension. Am J Hypertens. 2012 Jun;25(6):640-3. doi: 10.1038/ajh.2012.20. Epub 2012 Mar 8. PubMed PMID:22402472.
- Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus. Free Radic Biol Med. 1998 Nov 1;25(7):757-65. PubMed PMID:9823540.
- Acute l-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance Stephen J. Bailey, Paul G. Winyard, Anni Vanhatalo, Jamie R. Blackwell, Fred J. DiMenna, Daryl P. Wilkerson, and Andrew M. Jones Journal of Applied Physiology 2010 109:5, 1394-1403
- Paddon-Jones D, Børsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S; discussion 2895S. Review. PubMed PMID: 15465806.
- Zhang CG, Kim SJ. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann Nutr Metab. 2007;51(4):379-86. Epub 2007 Aug 29. PubMed PMID: 17728537.
- Balshaw TG, Bampouras TM, Barry TJ, Sparks SA. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners. Amino Acids. 2013 Feb;44(2):555-61. doi: 10.1007/s00726-012-1372-1. Epub 2012 Aug 2. PubMed PMID: 22855206.
- Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. 2010 Aug;20(4):322-9. PubMed PMID: 20739720.
- Dunnett M, Harris RC. Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius. Equine Vet J Suppl. 1999 Jul;(30):499-504. PubMed PMID: 10659307.
- Hipkiss AR. On the enigma of carnosine's anti-ageing actions. Exp Gerontol. 2009 Apr;44(4):237-42. doi: 10.1016/j.exger.2008.11.001. Epub 2008 Nov 11. PubMed PMID: 19041712.
- Boldyrev AA. Does carnosine possess direct antioxidant activity? Int J Biochem. 1993 Aug;25(8):1101-7. Review. PubMed PMID: 8405650.
- Kohen R, Yamamoto Y, Cundy KC, Ames BN. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA. 1988 May;85(9):3175-9. PubMed PMID: 3362866; PubMed Central PMCID: PMC280166.
- Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E. Protective effect of carnosine during nitrosative stress in astroglial cell cultures. Neurochem Res. 2005 Jun-Jul;30(6-7):797-807. PubMed PMID: 16187215.
- Joe A. Vinson, Thomas B. Howard, Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients, The Journal of Nutritional Biochemistry, Volume 7, Issue 12, 1996, Pages 659-663, ISSN 0955-2863, https://doi.org/10.1016/S0955-2863(96)00128-3.
- Hoffman J, Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JA. Beta-alanine and the hormonal response to exercise. Int J Sports Med. 2008 Dec;29(12):952-8. doi: 10.1055/s-2008-1038678. Epub 2008 Jun 11. PubMed PMID: 18548362.
- Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. 2008 May;34(4):547-54. doi: 10.1007/s00726-007-0008-3. Epub 2008 Jan 4. PubMed PMID: 18175046.
- Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E. beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol (1985). 2007 Nov;103(5):1736-43. Epub 2007 Aug 9. PubMed PMID: 17690198.
- Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37. doi: 10.1007/s00726-011-1200-z. Epub 2012 Jan 24. PubMed PMID: 22270875; PubMed Central PMCID: PMC3374095.
- Verster JC, Koenig J. Caffeine intake and its sources: a review of national representative studies. Crit Rev Food Sci Nutr. 2018;58(8):1250–9.
- Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr. 2010;7(1):5.
- Zaragoza, J., Tinsley, G., Urbina, S. et al. Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes. J Int Soc Sports Nutr 16, 56 (2019) doi:10.1186/s12970-019-0326-3
- Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011 Feb 15;18(4):235-44. doi: 10.1016/j.phymed.2010.08.014. Epub 2010 Oct 30. Review. PubMed PMID: 21036578.
- Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71. PubMed PMID: 11081987.
- Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. PubMed PMID: 10839209.
- Spasov AA, Mandrikov VB, Mironova IA. [The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load]. Eksp Klin Farmakol. 2000 Jan-Feb;63(1):76-8. Russian. PubMed PMID: 10763116.
- Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. PubMed PMID: 12725561.
- De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307. PubMed PMID: 15256690.
- Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006 Feb;197(2):309-17. Epub 2005 Dec 20. PubMed PMID: 16364299.
- Xu Y, Lin D, Li S, Li G, Shyamala SG, Barish PA, Vernon MM, Pan J, Ogle WO. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology. 2009 Sep;57(4):463-71. doi: 10.1016/j.neuropharm.2009.06.010. Epub 2009 Jun 21. PubMed PMID: 19540859.
- Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015 May;21(5):332-8. doi: 10.1007/s11655-015-2160-z. Epub 2015 Mar 17. PubMed PMID: 25776839.
- Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85. doi: 10.1002/ptr.5025. Epub 2013 Jul 6. PubMed PMID: 23832433.
- Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-75. doi: 10.1016/j.jad.2014.06.001. Epub 2014 Jun 11. PubMed PMID: 25046624.
- Panahi Y, Badeli R, Karami GR, Sahebkar A. Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive Phytother Res. 2015 Jan;29(1):17-21. doi: 10.1002/ptr.5211. Epub 2014 Aug 4. PubMed PMID: 25091591.
- Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9. doi: 10.1016/j.nutres.2012.09.002. Epub 2012 Oct 15. PubMed PMID: 23146777.
- DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79. PubMed PMID: 23013352; PubMed Central PMCID: PMC3518252.
- Pulido-Moran, Mario et al. “Curcumin and Health.” Molecules (Basel, Switzerland) 21,3 264. 25 Feb. 2016, doi:10.3390/molecules21030264
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence ofpiperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. PubMed PMID: 9619120.
AVVERTENZE
- Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Due to the presence of creatine, the product is intended for adults only. Do not use during pregnancy, breastfeeding, or in children, or for prolonged periods without consulting a doctor. Keep out of reach of children under 3 years of age. Store in a cool, dry place. Avoid exposure to localized heat sources and sunlight. The minimum shelf life refers to the product properly stored in an unopened package. Do not dispose of in the environment after use.
- Intolerances and lifestyles:
REAL FUEL is a gluten-free and lactose-free food supplement, suitable for both coeliac individuals and those with lactose intolerance. It is also an ideal product to supplement a vegetarian diet.
Ingredienti:
Creatina monoidrato, L-citrullina DL-malato, beta alanina, L-leucina, taurina, L-arginina alfa-chetoglutarato (AAKG), acidificante: acido citrico; destrine resistenti, addensante: isomalto; L-isoleucina, L-valina, aromi, succo concentrato disidratato di arancia, carota e limone, rodiola (Rhodiola rosea L.) radice e.s. tit. 3% rosavine totali, agente antiagglomerante: biossido di silicio; CAVACURMIN® [curcuma (Curcuma longa L.), gamma-ciclodestrina] rizoma e.s. tit. 15% curcuminoidi, L-teanina, caffeina anidra, edulcorante: sucralosio; stabilizzanti: esteri di saccarosio degli acidi grassi, idrossi-propil-metilcellulosa; piridossina cloridrato (vitamina B6), pepe nero (Piper nigrum L.) frutto e.s. tit. 95% piperina, acido pteroil-monoglutammico (acido folico), cianocobalamina (vitamina B12).
- The recommended daily intake is 15 g (equal to 1 level scoop) dissolved in 300 ml of water.
A 15 g dose consists of:
- 3 g of Creatine for an instant increase in phosphocreatine (CP) stores [1], which is of fundamental importance for ATP synthesis in short and medium-duration high-intensity efforts; to ensure adequate cell hydration and hypertonicity [2], given the fluid loss due to physical activity; for a reduction in fatigue [3] in chronic states and sleep deprivation [4]; for better glucose uptake within the cell [5] and therefore its adequate use for energy purposes; for increasing lean mass and the diameter of type I, IIa, and IIx muscle fibers [6].
- L-Citrulline is an amino acid that promotes nitric oxide synthesis (NOS) [16,17], which doubles the levels of L-Arginine and L-Ornithine already present in the body [15], thereby increasing the vasodilatory effect and thus a greater influx of nutrients. Citrulline promotes glycogenolysis and glycolysis, thereby increasing ATP production [18], which is essential for continuous muscle contraction. Furthermore, it mitigates the depletion of phosphocreatine stores (the active form of creatine) and promotes their restoration [19], thus reducing the waiting time to repeat an explosive movement.
- L-Arginine alpha-ketoglutarate is an amino acid that directly induces nitric oxide synthesis [20], thereby increasing blood flow also thanks to the coadjuvant action of Citrulline [21]. L-Arginine administration has been shown to increase anaerobic performance in sprints and delay the onset of fatigue symptoms [23]. L-Arginine also has a protective function for pancreatic β cells and improves insulin secretion [22]. The combination of L-Arginine and Creatine increases anaerobic performance and muscle mass, in addition to improving the rate of ATP resynthesis during muscle effort [24].
- Taurine is another essential amino acid for muscle function in both the musculoskeletal system and the heart, as well as the eyes. In sports, it is very useful in performance by improving aerobic capacity [26,27].
- β-Alanine is a modified version of the amino acid ⍺-alanine, and is the most important extracellular substrate for increasing carnosine concentrations within the cell [28], responsible for the buffering effect on intramuscular pH, as well as being a powerful anti-aging [29] and antioxidant molecule [30], reducing protein alteration from reactive oxygen species (ROS) [31], reactive nitrogen species (RNS) [32], and advanced glycation end products (AGEs) [33]. β-alanine has been shown to increase power expression in strength endurance [34,35] and in the endurance of sprinters in repeated maximal efforts [36]. β-alanine is particularly effective in all sports where performance ranges from 60 to 240 seconds [37], as well as in all sports with intermittent efforts.
- Caffeine is a natural alkaloid classified as a nootropic, meaning a stimulant that acts at the brain level giving greater focus, reactivity, and cognition, but it is also a mild anti-inflammatory, antioxidant, associated with the prevention of gastrointestinal neoplasms [38,39]. L-Theanine is an amino acid found in tea that, together with Caffeine, works synergistically to increase concentration, mitigating the undesirable effects of the latter if in excess [40].
- A pool of branched-chain amino acids, BCAAs in a 2:1:1 ratio (L-Leucine 1.0 g; L-Isoleucine 0.5 g; L-Valine 0.5 g), primarily promotes glucose uptake via the PI3K/aPKC pathway, independent of the mTOR pathway, and its utilization in the cell [7][8][9]. Furthermore, they perform a particular neuronal activation function [10], as they would compete with the same tryptophan uptake pathway [11], responsible for increased fatigue during training, so their integration before and during training would increase neuronal excitation via mTOR [12], thus allowing greater focus and a delay in the onset of fatigue [13][14].
- Rhodiola Rosea is an adaptogen associated with a reduction in physical and mental fatigue [41], an increase in cognitive function [42,43,44,45] and neuro-motor function [43], a reduction in the margin of error [43], an increase in the attention threshold [46] and reaction time to stimuli [46], and more generally an improvement in the sense of well-being [43,44].
- CAVACURMIN® is a registered trademark dry extract of curcumin. Curcumin has been shown to prevent and block the degeneration of cognitive function in states of chronic stress [47,48]; furthermore, curcuminoids reduce depressive symptoms by increasing well-being [49,50,51,52]. Curcumin has a protective function at the endothelial level and increases nitric oxide production [53,54], and finally, it has been shown to be a molecule with antioxidant and anti-inflammatory properties [55]. Piper nigrum l. increases the absorption of curcuminoids by twentyfold [56].
- Brault JJ, Towse TF, Slade JM, Meyer RA. Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation. Int J Sport Nutr Exerc Metab. 2007 Dec;17(6):624-34. PubMed PMID: 18156666.
- Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):70-91. PubMed PMID: 17460334.
- Watanabe A, Kato N, Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res. 2002 Apr;42(4):279-85. PubMed PMID:11985880.
- McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, Dye L, Hodgson C, Draper N. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006 Mar;185(1):93-103. Epub 2006 Jan 17. PubMed PMID: 16416332.
- Op 't Eijnde B, Ursø B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes. 2001 Jan;50(1):18-23. PubMed PMID: 11147785.
- Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003 Jun;13(2):198-226. PubMed PMID: 12945830.
- Nishitani S, Matsumura T, Fujitani S, Sonaka I, Miura Y, Yagasaki K. Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun. 2002 Dec 20;299(5):693-6. PubMed PMID: 12470633.
- Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E. Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J. 2004 Dec;18(15):1894-6. Epub 2004 Oct 12. PubMed PMID: 15479767.
- Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucoseoxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1683-93. Epub 2007 Feb 13. PubMed PMID: 17299083.
- Blomstrand E. A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006 Feb;136(2):544S-547S. PubMed PMID: 16424144.
- Blomstrand E, Møller K, Secher NH, Nybo L. Effect of carbohydrate ingestion on brain exchange of amino acids during sustained exercise in human subjects. Acta Physiol Scand. 2005 Nov;185(3):203-9. PubMed PMID: 16218925.
- Ament W, Verkerke GJ. Exercise and fatigue. Sports Med. 2009;39(5):389-422. doi: 10.2165/00007256-200939050-00005. Review. PubMed PMID: 19402743.
- Jin G, Kataoka Y, Tanaka M, Mizuma H, Nozaki S, Tahara T, Mizuno K, Yamato M, Watanabe Y. Changes in plasma and tissue amino acid levels in an animal model of complex fatigue. Nutrition. 2009 May;25(5):597-607. doi:10.1016/j.nut.2008.11.021. Epub 2009 Feb 11. PubMed PMID: 19216057.
- BLOMSTRAND, E. , HASSMÉN, P. and NEWSHOLME, E. A. (1991), Effect of branched‐chain amino acid supplementation on mental performance. Acta Physiologica Scandinavica, 143: 225-226. doi:1111/j.1748-1716.1991.tb09225.x
- Thibault R, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, Darmaun D. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. 2011 Dec;30(6):807-11. doi: 10.1016/j.clnu.2011.06.005. Epub 2011 Jul 5. PubMed PMID: 21733603.
- Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling; L Castillo, L Beaumier, A M Ajami, V R Young; Proceedings of the National Academy of Sciences Oct 1996, 93 (21) 11460-11465; DOI: 10.1073/pnas.93.21.11460
- Rougé C, Des Robert C, Robins A, Le Bacquer O, Volteau C, De La Cochetière MF, Darmaun D. Manipulation of citrulline availability in humans. Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1061-7. Epub 2007 Sep 27. PubMed PMID: 17901164.
- Faure C, Morio B, Chafey P, Le Plénier S, Noirez P, Randrianarison-Huetz V, Cynober L, Aussel C, Moinard C. Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats. Proteomics. 2013 Jul;13(14):2191-201. doi: 10.1002/pmic.201200262. Epub 2013 Jun 10. PubMed PMID: 23592530.
- Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002 Aug;36(4):282-9. PubMed PMID: 12145119; PubMed Central PMCID: PMC1724533.
- Bailey SJ, Winyard PG, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, Jones AM. Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance. J Appl Physiol (1985). 2010 Nov;109(5):1394-403. doi: 10.1152/japplphysiol.00503.2010. Epub 2010 Aug 19. PubMed PMID: 20724562.
- Figueroa A, Sanchez-Gonzalez MA, Wong A, Arjmandi BH. Watermelon extract supplementation reduces ankle blood pressure and carotid augmentation index in obese adults with prehypertension or hypertension. Am J Hypertens. 2012 Jun;25(6):640-3. doi: 10.1038/ajh.2012.20. Epub 2012 Mar 8. PubMed PMID:22402472.
- Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus. Free Radic Biol Med. 1998 Nov 1;25(7):757-65. PubMed PMID:9823540.
- Acute l-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance Stephen J. Bailey, Paul G. Winyard, Anni Vanhatalo, Jamie R. Blackwell, Fred J. DiMenna, Daryl P. Wilkerson, and Andrew M. Jones Journal of Applied Physiology 2010 109:5, 1394-1403
- Paddon-Jones D, Børsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S; discussion 2895S. Review. PubMed PMID: 15465806.
- Zhang CG, Kim SJ. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann Nutr Metab. 2007;51(4):379-86. Epub 2007 Aug 29. PubMed PMID: 17728537.
- Balshaw TG, Bampouras TM, Barry TJ, Sparks SA. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners. Amino Acids. 2013 Feb;44(2):555-61. doi: 10.1007/s00726-012-1372-1. Epub 2012 Aug 2. PubMed PMID: 22855206.
- Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. 2010 Aug;20(4):322-9. PubMed PMID: 20739720.
- Dunnett M, Harris RC. Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius. Equine Vet J Suppl. 1999 Jul;(30):499-504. PubMed PMID: 10659307.
- Hipkiss AR. On the enigma of carnosine's anti-ageing actions. Exp Gerontol. 2009 Apr;44(4):237-42. doi: 10.1016/j.exger.2008.11.001. Epub 2008 Nov 11. PubMed PMID: 19041712.
- Boldyrev AA. Does carnosine possess direct antioxidant activity? Int J Biochem. 1993 Aug;25(8):1101-7. Review. PubMed PMID: 8405650.
- Kohen R, Yamamoto Y, Cundy KC, Ames BN. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA. 1988 May;85(9):3175-9. PubMed PMID: 3362866; PubMed Central PMCID: PMC280166.
- Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E. Protective effect of carnosine during nitrosative stress in astroglial cell cultures. Neurochem Res. 2005 Jun-Jul;30(6-7):797-807. PubMed PMID: 16187215.
- Joe A. Vinson, Thomas B. Howard, Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients, The Journal of Nutritional Biochemistry, Volume 7, Issue 12, 1996, Pages 659-663, ISSN 0955-2863, https://doi.org/10.1016/S0955-2863(96)00128-3.
- Hoffman J, Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JA. Beta-alanine and the hormonal response to exercise. Int J Sports Med. 2008 Dec;29(12):952-8. doi: 10.1055/s-2008-1038678. Epub 2008 Jun 11. PubMed PMID: 18548362.
- Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. 2008 May;34(4):547-54. doi: 10.1007/s00726-007-0008-3. Epub 2008 Jan 4. PubMed PMID: 18175046.
- Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E. beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol (1985). 2007 Nov;103(5):1736-43. Epub 2007 Aug 9. PubMed PMID: 17690198.
- Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37. doi: 10.1007/s00726-011-1200-z. Epub 2012 Jan 24. PubMed PMID: 22270875; PubMed Central PMCID: PMC3374095.
- Verster JC, Koenig J. Caffeine intake and its sources: a review of national representative studies. Crit Rev Food Sci Nutr. 2018;58(8):1250–9.
- Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr. 2010;7(1):5.
- Zaragoza, J., Tinsley, G., Urbina, S. et al. Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes. J Int Soc Sports Nutr 16, 56 (2019) doi:10.1186/s12970-019-0326-3
- Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011 Feb 15;18(4):235-44. doi: 10.1016/j.phymed.2010.08.014. Epub 2010 Oct 30. Review. PubMed PMID: 21036578.
- Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71. PubMed PMID: 11081987.
- Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. PubMed PMID: 10839209.
- Spasov AA, Mandrikov VB, Mironova IA. [The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load]. Eksp Klin Farmakol. 2000 Jan-Feb;63(1):76-8. Russian. PubMed PMID: 10763116.
- Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. PubMed PMID: 12725561.
- De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307. PubMed PMID: 15256690.
- Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006 Feb;197(2):309-17. Epub 2005 Dec 20. PubMed PMID: 16364299.
- Xu Y, Lin D, Li S, Li G, Shyamala SG, Barish PA, Vernon MM, Pan J, Ogle WO. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology. 2009 Sep;57(4):463-71. doi: 10.1016/j.neuropharm.2009.06.010. Epub 2009 Jun 21. PubMed PMID: 19540859.
- Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015 May;21(5):332-8. doi: 10.1007/s11655-015-2160-z. Epub 2015 Mar 17. PubMed PMID: 25776839.
- Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85. doi: 10.1002/ptr.5025. Epub 2013 Jul 6. PubMed PMID: 23832433.
- Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-75. doi: 10.1016/j.jad.2014.06.001. Epub 2014 Jun 11. PubMed PMID: 25046624.
- Panahi Y, Badeli R, Karami GR, Sahebkar A. Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive Phytother Res. 2015 Jan;29(1):17-21. doi: 10.1002/ptr.5211. Epub 2014 Aug 4. PubMed PMID: 25091591.
- Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9. doi: 10.1016/j.nutres.2012.09.002. Epub 2012 Oct 15. PubMed PMID: 23146777.
- DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79. PubMed PMID: 23013352; PubMed Central PMCID: PMC3518252.
- Pulido-Moran, Mario et al. “Curcumin and Health.” Molecules (Basel, Switzerland) 21,3 264. 25 Feb. 2016, doi:10.3390/molecules21030264
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence ofpiperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. PubMed PMID: 9619120.
- Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Due to the presence of creatine, the product is intended for adults only. Do not use during pregnancy, breastfeeding, or in children, or for prolonged periods without consulting a doctor. Keep out of reach of children under 3 years of age. Store in a cool, dry place. Avoid exposure to localized heat sources and sunlight. The minimum shelf life refers to the product properly stored in an unopened package. Do not dispose of in the environment after use.
- Intolerances and lifestyles:
REAL FUEL is a gluten-free and lactose-free food supplement, suitable for both coeliac individuals and those with lactose intolerance. It is also an ideal product to supplement a vegetarian diet.
DOMANDE FREQUENTI
I'm looking for a product that doesn't give me too much of an initial boost followed by a crash, but rather remains constant. Is Real Fuel right for me?
Real Fuel was specifically designed to maintain constant energy during training. Creatine, L-Citrulline, and L-Arginine promote rapid restoration of ATP stores for quick energy and reduced latency between contractions; β-Alanine extends contraction time by delaying the onset of fatigue; Taurine ensures and promotes muscle contraction in addition to its anti-stress function; Caffeine, L-Theanine, and Rhodiola Rosea help increase concentration during training sessions or competitions; BCAAs and B vitamins provide a substrate for all cellular processes during exertion; turmeric extract alleviates mild anxiety related to athletic performance, as well as providing antioxidant and anti-inflammatory protection; black pepper acts as an adjuvant to maximize curcumin absorption.
How does Real Fuel increase my focus?
The secret lies in its ingredients: Caffeine, L-Theanine, and Rhodiola Rosea help increase concentration during training sessions or competitions. In addition, turmeric extract alleviates mild anxiety related to sports performance.
Is Real Fuel only a PRE-workout, or can I take it at a different time of day?
Its use was designed to maximize physical and mental performance, but in relation to training or competition.

